Browsing by Author "Erbaba, Begün"
Now showing items 1-6 of 6
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Effects of aging and short-term dietary restriction on neurogenesis and cellular senescence in the zebrafish (Danio Reio) brain
(Bilkent University, 2016-09)Currently we know from rodent and fish studies that adult neuron generation is reduced but still continues in old animals with a dynamic change throughout aging. This process occurs mainly in hippocampal region, which is ... -
Effects of caloric restriction on the antagonistic and integrative hallmarks of aging
(Elsevier, 2021)Aging is a significant risk factor for cognitive decline associated with neurodegenerative diseases, which makes understanding what promotes ‘healthy brain aging’ very important. Studies suggest that caloric restriction ... -
TERT distal promoter GC islands are critical for telomerase and together with DNMT3B silencing may serve as a senescence-inducing agent in gliomas
(Taylor & Francis Inc., 2022-08-23)Telomerase is reactivated in the majority of cancers. For instance, in gliomas, it is common that the TERT promoter is mutated. Research on telomere promoter GC islands have been focused primarily on proximal TERT promoter ... -
Transcriptomic alterations in the aged brain with and without dietary and dietary- mimetic manipulations
(Bilkent University, 2021-12)Aside from many genetic and environmental influences on the brain, aging itself is a significant risk factor for accelerated cognitive decline, making aging research crucial due to the increasing population age in our era. ... -
Zebrafish aging models and possible interventions
(InTechOpen Press, 2018)Across the world, the aging population is expanding due to an increasing average life expectancy. The percentage of elderly over the age of 65 is expected to be more than 15% of the total world population by 2025. As the ... -
Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging
(Elsevier, 2020)Brain aging is a complex process, which involves multiple pathways including various components from cellular to molecular. This study aimed to investigate the gene expression changes in zebrafish brains through young-adult ...
