Now showing items 1-5 of 5

    • BO-264: Highly potent TACC3 inhibitor as a novel anticancer drug candidate 

      Akbulut, Özge (Bilkent University, 2021-01)
      Breast cancer has been consistently ranked to be the most common cancer and the second leading cause of cancer-related death in women worldwide for many years. Despite better understanding of tumor biology and the availability ...
    • A highly potent TACC3 inhibitor as a novel anticancer drug candidate 

      Akbulut, Özge; Lengerli, D.; Saatci, Özge; Duman, Elif; Şeker, Urartu Özgür Şafak; Işık, A.; Akyol, A.; Çalışkan, B.; Banoğlu, E.; Şahin, Özgür (NLM (Medline), 2020)
      TACC3, a transforming acidic coiled-coil (TACC) family member, is frequently upregulated in a broad spectrum of cancers, including breast cancer. It plays critical roles in protecting microtubule stability and centrosome ...
    • Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer 

      Saatçi, Ö.; Kaymak, A.; Raza, Umar; Ersan, Pelin G.; Akbulut, Özge; Banister, C. E.; Sikirzhytski, V.; Tokat, Ünal Metin; Aykut, Gamze; Ansari, Suhail A.; Tatlı-Doğan, H.; Doğan, M.; Jandaghi, P.; Işık, A.; Gündoğdu, F.; Kösemehmetoğlu, K.; Dizdar, Ö.; Aksoy, S.; Akyol, A.; Üner, A.; Buckhaults, P. J.; Riazalhosseini, Y.; Şahin, Özgür (Nature Research, 2020)
      Chemoresistance is a major obstacle in triple negative breast cancer (TNBC), the most aggressive breast cancer subtype. Here we identify hypoxia-induced ECM re-modeler, lysyl oxidase (LOX) as a key inducer of chemoresistance ...
    • Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer 

      Saatçi, Özge; Borgoni, S.; Akbulut, Özge; Durmuş, Selvi; Raza, Umar; Eyüpoğlu, Erol; Alkan, Can; Akyol, A.; Kütük, Ö.; Wiemann, S.; Şahin, Özgür (Nature Publishing Group, 2018)
      Trastuzumab-refractory, HER2 (human epidermal growth factor receptor 2)-positive breast cancer is commonly treated with trastuzumab emtansine (T-DM1), an antibody-drug conjugate of trastuzumab and the microtubule-targeting ...
    • Universality of dissipative self-assembly from quantum dots to human cells 

      Makey, Ghaith; Galioğlu, Sezin; Ghaffari, Roujin; Engin, E. D.; Yıldırım, Gökhan; Yavuz, Özgün; Bektaş, O.; Nizam, Ü. S.; Akbulut, Özge; Şahin, Özgür; Güngör, Kıvanç; Dede, Didem; Demir, Hilmi Volkan; İlday, Fatih Ömer; İlday, Serim (Nature Research, 2020)
      An important goal of self-assembly research is to develop a general methodology applicable to almost any material, from the smallest to the largest scales, whereby qualitatively identical results are obtained independently ...