Now showing items 1-11 of 11

    • Autonomous synthesis of fluorescent silica biodots using engineered fusion proteins 

      Ölmez, Tolga T.; Yuca, Esra; Eyüpoğlu, Erol; Çatalak, Hazal B.; Şahin, Özgür; Şeker, Urartu Özgür Şafak (American Chemical Society, 2018)
      Formation of biological materials is a well-controlled process that is orchestrated by biomolecules such as proteins. Proteins can control the nucleation and mineralization of biomaterials, thereby forming the hard tissues ...
    • Biomedical and biochemical tools of förster resonance energy transfer enabled by colloidal quantum dot nanocrystals for life sciences 

      Şeker, Urartu Özgür Şafak; Demir, Hilmi Volkan (Springer Berlin Heidelberg, 2013)
      Semiconductor quantum nanocrystals (NCs) provide the ability to control and fine-tune peak emission wavelength using the size effect, with a broad optical absorption band (excitation window) increasing toward UV wavelength ...
    • Biomineralization of calcium phosphate crystals controlled by protein-protein interactions 

      Duman, Elif; Şahin-Kehribar, Ebru; Ahan, Recep Erdem; Yuca, Esra; Şeker, Urartu Özgür Şafak (American Chemical Society, 2019)
      Hydroxyapatite (HAP) is the major biomineral of bone. Despite the large number of studies addressing HAP formation, a fundamental understanding of the critical roles of HAP-forming proteins in vitro is needed. Effects of ...
    • Cellular biocatalysts using synthetic genetic circuits for prolonged and durable enzymatic activity 

      Ahan, Recep Erdem; Şaltepe, Behide; Apaydın, Onur; Şeker, Urartu Özgür Şafak (Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim, 2019)
      Cellular biocatalysts hold great promise for the synthesis of difficult to achieve compounds, such as complex active molecules. Whole‐cell biocatalysts can be programmed through genetic circuits to be more efficient, but ...
    • Cellular biosensors with engineered genetic circuits 

      Saltepe, Behide; Kehribar, Ebru Şahin; Yirmibeşoǧlu, Side Selin Su; Şeker, Urartu Özgür Şafak (American Chemical Society, 2018)
      An increasing interest in building novel biological devices with designed cellular functionalities has triggered the search of innovative tools for biocomputation. Utilizing the tools of synthetic biology, numerous genetic ...
    • Characterization of local SARS-CoV-2 isolates and pathogenicity in IFNAR−/- mice 

      Hanifehnezhad, A.; Kehribar, Ebru Şahin; Öztop, S.; Sheraz, Ali; Kasırga, Serkan; Ergünay, K.; Önder, S.; Yılmaz, E.; Engin, D.; Oğuzoğlu, T. Ç.; Şeker, Urartu Özgür Şafak; Yılmaz, E.; Özkul, A. (Elsevier, 2020)
      The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently a global pandemic with unprecedented public health, economic and social impact. The development of effective mitigation strategies, therapeutics and ...
    • Genetic logic gates enable patterning of amyloid nanofibers 

      Kalyoncu, Ebuzer; Ahan, Recep Erdem; Özçelik, Cemile Elif; Şeker, Urartu Özgür Şafak (WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2019)
      Distinct spatial patterning of naturally produced materials is observed in many cellular structures and even among communities of microorganisms. Reoccurrence of spatially organized materials in all branches of life is ...
    • A highly potent TACC3 inhibitor as a novel anticancer drug candidate 

      Akbulut, Özge; Lengerli, D.; Saatci, Özge; Duman, Elif; Şeker, Urartu Özgür Şafak; Işık, A.; Akyol, A.; Çalışkan, B.; Banoğlu, E.; Şahin, Özgür (NLM (Medline), 2020)
      TACC3, a transforming acidic coiled-coil (TACC) family member, is frequently upregulated in a broad spectrum of cancers, including breast cancer. It plays critical roles in protecting microtubule stability and centrosome ...
    • Self-assembly of bacterial amyloid protein nanomaterials on solid surfaces 

      Onur, Tuğçe; Yuca, Esra; Ölmez, Tolga Tarkan; Şeker, Urartu Özgür Şafak (Academic Press, 2018)
      Hypothesis: Amyloid-forming biofilm proteins of Escherichia coli, namely CsgA and CsgB, can form self-assembled nanofibers on solid surfaces. These proteins can be programmed to form bio-nanomaterials for functional ...
    • A sustainable preparation of catalytically active and antibacterial cellulose metal nanocomposites via ball milling of cellulose 

      Kwiczak-Yiğitbaşı, Joanna; Laçin, Özge; Demir, Mine; Ahan, Recep Erdem; Şeker, Urartu Özgür Şafak; Baytekin, Bilge (Royal Society of Chemistry, 2020-01)
      Cellulose, the most abundant polymer on Earth, and its composites have recently gained importance for the production of sustainable materials. These materials should be produced using green methods that avoid the utilization ...
    • Synthetic genetic circuits for self-actuated cellular nanomaterial fabrication devices 

      Ölmez, Tolga Tarkan; Şahin-Kehribar, Ebru; Işılak, Musa Efe; Lu, T. K.; Şeker, Urartu Özgür Şafak (American Chemical Society, 2019)
      Genetically controlled synthetic biosystems are being developed to create nanoscale materials. These biosystems are modeled on the natural ability of living cells to synthesize materials: many organisms have dedicated ...