Browsing by Author "Çetin-Atalay, R."

Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles

Çikla-Süzgün P.; Kaushik-Basu, N.; Basu, A.; Arora P.; Talele, T.T.; Durmaz I.; Çetin-Atalay, R.; Küçükgüzel, S.G. (Taylor and Francis Ltd, 2015)

Arachidonic acid is an unsaturated fatty acid liberated from phospholipids of cell membranes. NSAIDs are known as targets of cyclooxygenase enzyme (COX-1, COX-2 and COX-3) in arachidonic acid metabolism. This mechanism of ...

Author correction: CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation (Scientific Reports, (2020), 10, 1, (5971), 10.1038/s41598-020-62912-0)

Ayaz, G.; Razizadeh, N.; Yaşar, P.; Kars, G.; Kahraman, D. C.; Saatci, Ö.; Şahin, Özgür; Çetin-Atalay, R.; Muyan, M. (Nature Research, 2020)

Automated cancer stem cell recognition in H and E stained tissue using convolutional neural networks and color deconvolution

Aichinger, W.; Krappe, S.; Çetin, A. Enis; Çetin-Atalay, R.; Üner, A.; Benz, M.; Wittenberg, T.; Stamminger, M.; Münzenmayer, C. (SPIE, 2017)

The analysis and interpretation of histopathological samples and images is an important discipline in the diagnosis of various diseases, especially cancer. An important factor in prognosis and treatment with the aim of a ...

Classification of human carcinoma cells using multispectral imagery

Çınar, U.; Çetin, Y. Y.; Çetin-Atalay, R.; Çetin, A. Enis (SPIE, 2016)

In this paper, we present a technique for automatically classifying human carcinoma cell images using textural features. An image dataset containing microscopy biopsy images from different patients for 14 distinct cancer ...

CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation

Ayaz, G.; Razizadeh, N.; Yaşar, P.; Kars, G.; Kahraman, D. C.; Saatci, Ö.; Şahin, Özgür; Çetin-Atalay, R.; Muyan, M. (Nature Research, 2020)

Evidence suggests that the CXXC type zinc finger (ZF-CXXC) protein 5 (CXXC5) is a critical regulator/integrator of various signaling pathways that include the estrogen (E2)-estrogen receptor α (ERα). Due to its ZF-CXXC ...

Çarpmasız yapay sinir ağı

Akbaş, Cem Emre; Bozkurt, Alican; Çetin, A. Enis; Çetin-Atalay, R.; Üner, A. (IEEE, 2015-05)

Bu bildiride çarpma işlemi kullanmadan oluşturulan bir Yapay Sinir Ağı (YSA) sunulmaktadır. Girdi vektörleri ve YSA katsayılarının iç çarpımları çarpmasız bir vektör işlemiyle hesaplanmıştır. Yapay sinir ağının eğitimi ...

EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers

Çiçek, E.; Çırçır, A.; Öyken, M.; Akbulut Çalışkan, Özge; Dioken, D. N.; Güntekin Ergün, S.; Çetin-Atalay, R.; Sapmaz, A.; Ovaa, H.; Şahin, Ö.; Erson-Bensan, A. E. (Nature Publishing Group, 2021-10-30)

Epidermal growth factor receptor (EGFR) has critical roles in epithelial cell physiology. Over-expression and over-activation of EGFR have been implicated in diverse cancers, including triple-negative breast cancers (TNBCs), ...

Mixture of learners for cancer stem cell detection using CD13 and H and E stained images

Oğuz, Oğuzhan; Akbaş, Cem Emre; Mallah, Maen; Taşdemir, K.; Akhan-Güzelcan, E.; Muenzenmayer, C.; Wittenberg, T.; Üner, A.; Çetin, A. Enis; Çetin-Atalay, R. (SPIE, 2016)

In this article, algorithms for cancer stem cell (CSC) detection in liver cancer tissue images are developed. Conventionally, a pathologist examines of cancer cell morphologies under microscope. Computer aided diagnosis ...

Targeting PI3K/AKT/mTOR pathway identifies differential expression and functional role of IL8 in liver cancer stem cell enrichment

Kahraman, D. C.; Kahraman, Tamer; Çetin-Atalay, R. (American Association for Cancer Research, 2019)

Activation of the PI3K/Akt/mTOR pathway is an important signaling mechanism involved in the development and the progression of liver cancer stem cell (LCSC) population during acquired Sorafenib resistance in advanced ...