Advisors
Now showing items 1-7 of 7
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Analysis of the ATAD2 gene effect on the genes involved in epithelial mesenchymal transition in estrogen positive and negative breast cancers
(Bilkent University, 2021-02)ATAD2 is overexpressed in many distinct cancer types including breast cancer. Its elevated expression is an indicator of poor prognosis. High ATAD2 expression correlates with short overall survival, disease-free survival ... -
Analysis of the effect of Erbin on the epithelial to mesenchymal transition related genes in breast cancer
(Bilkent University, 2022-09)Breast cancer is a heterogeneous disease and has complex mechanisms, which brings the need to come up with different approaches for its various types. Erbin is a member of the LAP family and directly interacts with ErbB2 ... -
Effects of PI3K/AKT/MTOR and VEGFR pathway inhibitors on liver cancer stem cells and bioactivities of novel pyrazolic chalcone derivatives on liver cancer
(Bilkent University, 2017-12)Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality, such that it the second most frequent cause of cancer death worldwide. Due to its heterogeneous composition and aggressive behavior, ... -
Evaluation of TAGLN as a diagnostic marker in breast cancer
(Bilkent University, 2018-08)Silecing of tumor suppressor genes via CpG hypermethylation in promoter regions is one of the frequent events occurring in different types of cancers. These genes have the potential as a diagnostic or a prognostic ... -
Functional analysis of Erbin gene in breast cancer drug resistance
(Bilkent University, 2021-02)Erbin is an ERBB2 interacting protein with roles in many signaling pathways. Breast cancer is one of the types of cancer that is affected by Erbin regulation. However, it is unclear how Erbin regulates the biological ... -
Functional analysis of transgelin in breast cancer
(Bilkent University, 2018-06)Transgelin (TAGLN) is an actin-binding protein. It is highly expressed in fibroblasts and smooth muscle cells. In smooth muscle cells, it takes part in processes including motility and differentiation and also it has a ... -
Role of histone variant H3.3 in transcription and mitotic progression
(Bilkent University, 2017-04)Chromatin structure needs to be dynamic and flexible in order for the eukaryotic cellular processes to function correctly. Incorporation of histone variants into chromatin serves to increase epigenetic plasticity by ...
