Advisors
Now showing items 1-20 of 34
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Bioactive peptide nanofibers for bone tissue regeneration
(Bilkent University, 2017-06)Replacement and repair of bone tissue that is lost due to fractures, tumor resection, degenerative diseases and infections still remain major clinical challenges. Autografting, allografting and xenografting are the current ... -
Bioactive peptide nanofibers for acceleration of burn wound healing
(Bilkent University, 2017-05)Burn injuries are one of the most typical types of trauma worldwide, and the unique physiology of burn injuries requires the use of specialized therapeutic materials for treatment and makes the development of such materials ... -
Bioactive peptide nanofibers for tissue regeneration
(Bilkent University, 2016-01)Defects in the tissues or organs caused by trauma or diseases can have detrimental effects on all aspects of patients’ life quality. During the last three decades, considerable developments have been made in tissue engineering ... -
Bioinspired materials for regenerative medicine and drug delivery applications
(Bilkent University, 2016-10)The structural organization and functional capabilities of natural materials have inspired many technological and scientific developments. Biological systems are under constant pressure for innovation due to the constraints ... -
Biomacromolecules, molecules and functional nanoparticles for therapeutic and diagnostic applications
(Bilkent University, 2016-03)Cancer is one of the most important global health problem. In the last decade, researchers have focused on the development of novel sensitive diagnostic agents and potential therapeutic molecules to further contribute to ... -
Biomimetic self-assembled peptide nanofibers for bone regeneration
(Bilkent University, 2012)Self-assembled peptide nanofibers are exploited in regenerative medicine applications due to their versatile, biofunctional and extracellular-matrixresembling structures. These properties provide peptide nanofibers ... -
Biotinylated peptide nanofibers for modulating the immune response
(Bilkent University, 2016-06)Despite the fact that vaccination eradicates many diseases, a broad variety of disorders cannot be treated using current vaccine development methods. In addition, it is difficult to rapidly develop new vaccines following ... -
Cell penetrating peptide amphiphile integrated liposomal systems for enhanced delivery of cargo to tumor cells
(Bilkent University, 2013)Liposomes have been extensively utilized as effective nanocarriers due to their enhanced solubility, higher stability and greater ability to facilitate the slow release of encapsulated drugs compared to free drug ... -
Characterization and corneal tissue engineering application of peptide amphiphiles
(Bilkent University, 2012)Molecular self-assembly is a powerful technique for developing novel nanostructures by using non-covalent interactions such as hydrogen bonding, hydrophobic, electrostatic, metal-ligand, π-π and van der Waals interactions. ... -
Characterization of peptide amphiphile nanofibers their interactions with chondroprogenitor cells and morphological analysis of tissues from transgenic animals
(Bilkent University, 2012)Peptide amphiphiles, molecules able to self assemble into three dimensional networks resembling to extracellular matrix which is excessive in cartilage tissue, are suitable candidates for overcoming cartilage tissue ... -
Design and application of nerve growth factor-β binding peptide nanofibers for neural regeneration
(Bilkent University, 2016-11)Promotion of neurite outgrowth is an important limiting step for the regeneration of nerve injury and depends strongly on the local expression of nerve growth factor (NGF). Rational design of bioactive materials is a ... -
Design and application of peptide nanofibers for modulating angiogenesis
(Bilkent University, 2016-06)Angiogenesis is important in many diseases, such as diabetic wound healing, cancer and corneal neovascularization. Angiogenesis can be induced or inhibited by complex biological systems. Mimicking the complexity in natural ... -
Design and development of ecm-inspired peptidebased nanostructures for bioengineering and biomedicine
(Bilkent University, 2017-08)Advances in understanding of cell-matrix interactions and the regulation of cellular behaviors through nanobiotechnological tools have presented new perspectives for regenerative medicine. Peptide amphiphiles have been ... -
Development and characterization of peptide nanofibers for cartilage regeneration
(Bilkent University, 2015-09)Articular cartilage is a tissue that is continuously exposed to cyclical compressive stresses, but exhibits no capacity for self-healing following trauma. Cartilage has a dense extracellular matrix that is sparsely ... -
Development of bioactive peptide nanofibers for intervertebral disc regeneration
(Bilkent University, 2017-08)Lower back pain (LBP) and neck problems are the most common orthopedic diseases worldwide, and the main reason behind LBP is intervertebral disc degeneration (IVDD). Therefore, specialized therapeutic applications to induce ... -
Development of peptide based materials as a synthetic scaffold to mimic extracellular matrix
(Bilkent University, 2017-07)Biomaterials obtained through self-assembling process of peptide amphiphile (PA) molecules provide great potential to introduce new therapeutic approaches in regenerative medicine through mimicking the natural environments ... -
Development of peptide nanomaterials for neural regeneration
(Bilkent University, 2015-05)Nervous system consists of a dense network of cells and their connections and exhibits a high level of complexity. This complexity arises from the high variety of cell types with very specific functions, the high number ... -
Eliciting immune response by using nanostructures
(Bilkent University, 2017-06)The ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation ... -
Genetics and mechanisms of essential tremor and related disorders
(Bilkent University, 2015)Neurodegenerative disorders are characterized by progressive nervous system dysfunction, and they remain as one of the most challenging disorders known to humankind. These disorders have devastating effects on patients ... -
Identification and characterization of exonic variants related with familial essential tremor
(Bilkent University, 2017-07)Essential tremor (ET) is the most common movement disorder in humans. Despite its high heritability and frequency, the genetic basis and pathophysiology of ET is not well understood. In this study, whole exome sequencing ...
