Advisors
Now showing items 1-18 of 18
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A-To-I RNA editing events, potential biomarkers for prognosis and chemosensitivity in gastric cancer
(Bilkent University, 2022-09)Gastric cancer (GC) is one of the leading causes of cancer mortality, and it frequently presents in advanced stages with a poor prognosis and response to treatment. Although extensive research has identified many potential ... -
Cancer testis gene expression as a biomarker of one-carbon metabolic activity, drug sensitivity and phenotypic heterogeneity in non-small cell lung cancer and malignant melanoma
(Bilkent University, 2016-09)Expression of cancer-testis (CT) genes on X chromosome (CT-X) is restricted to tumors, with very low or no expression in normal adult tissues. CT-X gene expression is one of the factors contributing to tumor heterogeneity ... -
Cancer-testis gene expression as a biomarker of the genetic variation in the one carbon metabolic pathway
(Bilkent University, 2008)S-adenosyl methionine (SAM) is the sole methyl donor for all biological reactions in humans. Folate consumption, required for SAM generation, is also essential for dTMP synthesis and both events occur via enzymes of the ... -
Characterization of chemosensitivity profiles of breast cancer cell lınes, with and without stem cell like features = Kök-hücre özelliği olan ve olmayan meme kanseri hücre hatlarının ilaç hassasiyet profillerinin tanımlanması
(Bilkent University, 2014)Breast cancer is the second most common cause of death worldwide from cancer due to complications with its diagnosis and resistance to therapy. Recent studies have shown that breast tumors when compared with other solid ... -
Development and validation of methods for the diagnosis of lung cancer via serological biomarkers
(Bilkent University, 2019-02)Over 10% of all new cancer cases are lung cancer. Moreover, estimates till 2030 indicate that already increasing lung cancer incidences will keep increasing, especially in developing countries like Turkey. Lung cancer, the ... -
Development of methods for identification and characterization of autologous antibody responses in Small Cell Lung Cancer and Behcet’s Disease
(Bilkent University, 2016-08)Autologous antibodies are known to be elicited in Behçet’s Disease (BD) and Small Cell Lung Cancer (SCLC). SCLC consists 15-20% of all lung cancer cases. It is follows a most aggressive course and generally patients are ... -
Identification and utilization of autologous anti-tumor antibodies for the diagnosis and prognosis of cancer
(Bilkent University, 2015-12)Lung cancer is the leading cause of cancer related death worldwide. Current diagnostic methods have limited power and unable to extend patient life significantly. SCLC; the most aggressive subtype of lung cancer is an ... -
Identification of a novel experimental model to reveal mechanisms leading to epigenetic changes and subsequent activation of cancer testis genes in cancer
(Bilkent University, 2016-08)Epigenetic aberrations are frequently observed in cancer. Tumor-suppressor genes are often repressed with anomalous hypermethylation in cancer, while DNA hypomethylation has been identified in repetitive sequences and ... -
Identification of RNA-based biomarkers associated with manic episodes and lithium response in bipolar disorder
(Bilkent University, 2022-12)Bipolar disorder (BD) is one of the major mood disorders. A person afflicted with this neuropsychiatric disease undergoes episodes of depression and mania. BD ranks as the highest amongst all the mood disorders for having ... -
Identification of theranostic gene markers in cancers and prognostic validation in colorect al cancer
(Bilkent University, 2015-01)Colorectal cancer (CRC) is the fourth most prevalent cancer type worldwide. Although the 5-year survival rate of CRC is higher than many cancer types, prediction of prognosis and identification of accurate biomarkers still ... -
In silico validation of prognostic mRNA signature in gastric cancer and identification and validation of novel gastric tissue specific reference genes for quantitative PCR
(Bilkent University, 2021-07)Gastric adenocarcinoma is a molecularly and histologically heterogeneous neoplasm with a predictively disastrous outcome if undiagnosed at early stages. Amidst global declines of gastric cancer rates, it remains the 5th ... -
Multiomics approaches to overcome drug resistance in cancer
(Bilkent University, 2021-09)Chemotherapy resistance remains one of the major challenges in cancer treatment. Most of the studies on drug resistance have focused on genetic evolution of cancer cells; however, this focus has shifted to non-genetic and ... -
A novel role for 5-hmC in the regulation of cancer testis gene expression in cancer and mesenchymal to epithelial transition
(Bilkent University, 2014-12)Cancer/testis (CT) genes show highly restricted expression among normal tissues, limited to germ cells in the testis and ovary, and to trophoblast cells, , but are frequently expressed in various cancers. Other than a ... -
Prediction of prognosis and chemosensitivity in breast cancer
(Bilkent University, 2020-09)Breast cancer (BC) is responsible for the highest mortality and morbidity out of all the cancers in women which is primarily due to both inter and intra-tumoral molecular heterogeneity. This heterogeneity arises from ... -
Prediction of prognosis and chemosensitivity in gastrointestinal cancers
(Bilkent University, 2017-12)Colon and gastric cancers are the third and fifth cancer types with the poorest survival. Surgery is considered the primary treatment option, which can be curative. However the decision as to whether chemotherapy ... -
RNA based biomarkers for prediction of the endometrial window of implantation
(Bilkent University, 2020-12)Early reproductive failure is the most common issue related to successful pregnancies, as around 30% of all conceptions reach live birth. The path to a successful pregnancy is reliant on the successful implantation of the ... -
Transcript variants of CELF2 gene as unique prognostic indicators in breast cancer
(Bilkent University, 2022-08)Breast cancer (BC) is the most common malignant tumor in women around the world. Aside from finding a cure for this disease, it is also critical to identify prognostic biomarkers that can help clinicians intervene with the ... -
Validation of prognostic biomarkers for overall survival in melanoma patients undergoing autologous vaccination
(Bilkent University, 2014)Malignant Melanoma is deadliest type of skin cancer, seen with low frequency. Lack of diagnostic and prognostic markers are important obstacles during early detection and selection of appropriate adjuvant therapy for ...
