Advisors
Now showing items 1-8 of 8
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BO-264: Highly potent TACC3 inhibitor as a novel anticancer drug candidate
(Bilkent University, 2021-01)Breast cancer has been consistently ranked to be the most common cancer and the second leading cause of cancer-related death in women worldwide for many years. Despite better understanding of tumor biology and the availability ... -
Characterization of extracellular purinergic signaling components in colorectal carcinoma
(Bilkent University, 2021-01)Colorectal carcinoma is a heterogeneous disease which is the third leading cause of cancer-associated mortalities in the world. It is also reported to be the third most diagnosed cancer among other cancer types. The ... -
Deciphering IKBKE involvement in hepatocellular cancer HEPG2 cells
(Bilkent University, 2020-06)Hepatocellular carcinoma (HCC) is the second leading cause of cancer related deaths worldwide. The reasons behind high mortality in HCC patients include late diagnosis and lack of therapeutic option. Sorafenib is the only ... -
The effect of interleukin 7 on CD8+T cell accumulation and differentiation in the presence of adenosine signaling
(Bilkent University, 2020-01)Cytotoxic T cells are important cytotoxic adaptive immune cells. Their role is to check every single cell for protecting the body against microbial infections. They are also the main players for antigen-specific recognition ... -
Elucidation of Sorafenib resistance mechanisms in hepatocellular carcinoma
(Bilkent University, 2018-07)Hepatocellular Carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer-related deaths worldwide. Currently, Sorafenib is the only approved first-line treatment option for unresectable ... -
Identification of actionable drug targets in triple-negative breast cancer
(Bilkent University, 2022-09)Triple-negative breast cancer (TNBC) is the most aggressive subtype of the breast cancer, representing 15-20% of all cases. Due to a lack of clinically available/approved targeted therapies, TNBC patients are still in ... -
Identification of the roles played by IKKε in hepatocellular and colorectal carcinogenesis
(Bilkent University, 2018-07)Hepatocellular carcinomas (HCC) and colorectal carcinomas (CRC) are among the most common cancers worldwide with high mortality rates. While HCC affecting mostly underdeveloped countries, CRC is a disease that mainly occur ... -
Identifying TBK1-specific roles in colorectal cancer
(Bilkent University, 2022-06)Colorectal cancer (CRC) is the second most lethal cancer type, with a high incidence rate among adults. The CRC is a highly heterogenic disease with a high rate of mutations in different molecular pathways. Moreover, ...
