Advisors
Now showing items 1-8 of 8
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Characterization of a novel IRE1 substrate pact and interacting miRNAS
(Bilkent University, 2022-06)The double-stranded RNA-dependent protein kinase activator A (PACT) anchors the RNAinduced silencing complex (RISC) to the endoplasmic reticulum (ER)’s membranous platform where RISC nucleation occurs and thus, PACT plays ... -
Identification of a novel substrate of IRE1 in lipotoxic stress response
(Bilkent University, 2022-02)Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is a ribonucleic acid (RNA)-binding protein (RBP) that controls translation of select messenger RNAs (mRNAs). ... -
Investigating the targets and biological roles of IRE1’s two enzymatic activities
(Bilkent University, 2022-06)The unfolded protein response (UPR) is composed of complex and intricate series of highly regulated pathways geared to resolve the accumulation of misfolded proteins and to maintain cellular homeostasis. Endoplasmic reticulum ... -
Lipotoxic endoplasmic reticulum stress-associated inflammation : molecular mechanisms and modification by a bioactive lipokine
(Bilkent University, 2012)Physiologic or pathologic processes that disturb protein folding in the endoplasmic reticulum (ER) activate a signaling pathway named the unfolded protein response (UPR). UPR promotes cell survival by reducing misfolded ... -
The role of IRE1 in metaflammation and atherosclerosis
(Bilkent University, 2017-05)Chronic metabolic overloading of anabolic and catabolic organelles such as the endoplasmic reticulum (ER) and mitochondria is a major cause of inflammation in obesity. ER serves as a critical metabolic center for protein, ... -
The role of lipid-induced integrated stress response in metaflammation and atherosclerosis
(Bilkent University, 2019-07)Chronic inflammation resulting from metabolic overloading of organelles (such as the endoplasmic reticulum (ER) and mitochondria that control cellular homeostasis) is a major cause of metabolic disorders including diabetes, ... -
The role of Protein Kinase R in lipotoxicity
(Bilkent University, 2013)Endoplasmic reticulum (ER) is a central organelle for cellular homeostasis through its myriad of functions including protein and lipid biosynthesis, protein folding and secretion and calcium homeostasis. When protein ... -
Unfolded protein response regulated mirnas in lipotoxic endoplasmic reticulum stress in macrophages
(Bilkent University, 2014-07)The proper functioning and the development of the cell is essential to the fitness of the multicellular organisms - any significant disturbances in cellular mechanisms can lead to a multitude of diseases or death. Among ...
