Advisors
Now showing items 1-6 of 6
-
Identification of general transcription Factor-Two-E and mediator complex interactions in the context of pre-initiation complex formation
(Bilkent University, 2018-06)Transcription is a multistep process which requires the presence of many different proteins and protein complexes. The minimal protein components enabling transcription to happen are identified to execute the event in ... -
Investigating the role of the mediator complex in estrogen receptor alpha-mediated transcription
(Bilkent University, 2018-07)Mediator is the most important coregulator in eukaryotic transcription. It conveys the signals received from transcriptional activators on enhancer sequences to transcription machinery on promoter regions. Although Mediator ... -
POLR2A/RPB1 subunit of RNA polymerase II interacts with NTDMED14 containing core mediator complex to facilitate basal and activator driven transcription
(Bilkent University, 2020-06)The Metazoan Mediator is a 2-MDa protein complex that consist of 30 subunits, most of which are evolutionarily conserved from yeast to humans8. The maintenance and regulation of the cell is dependent on spatiotemporal ... -
Reconstitution of RNA Polymerase II subunits and analysis of their interaction with PIC components
(Bilkent University, 2018-08)Mediator Complex is a global coactivator of RNA Pol II transcription machinery. It transmits the regulatory signals from enhancer to promoter region. In the absence of Mediator Complex, Pol II transcription is defected. ... -
Reconstitution of the partial tail module of the human mediator complex
(Bilkent University, 2021-09)RNA Polymerase II (Pol II) regulates and maintains every aspect of the cell through the act of transcription of protein coding genes. Transcription of protein coding genes depends on extrinsic and intrinsic signals to the ... -
Revealing the role of Med14 in Pol-II transcription regulation
(Bilkent University, 2017-08)Transcription of protein coding genes by RNA polymerase II (Pol II) is a multi-step process each of which requires a series of factors including coactivators. 30-subunit (the subunits are organized into discrete modules ...
