Now showing items 1-20 of 21

    • Biomineralization with engineered cellular systems 

      Ergül, Elif (Bilkent University, 2019-08)
      Hydroxyapatite (HAP) is the final product of bone biomineralization process and HAP formation is controlled by proteins, enzymes and small molecules secreted to extracellular matrix (ECM). Among these molecules, alkaline ...
    • A cellular device to target cancer cells 

      Ostaku, Julian (Bilkent University, 2021-10)
      Cancer is the second leading cause of death globally, affecting one out of three people during their lifetime. Due to its severity and high incidence, numerous treatment methods have been implemented, with the Chimeric ...
    • Developing synthetic biology enabled whole cell biosensors 

      Saraylı, Side Selin Su (Bilkent University, 2017-12)
      Main causative agent for environmental pollution is human activities. Especially with accelerated industrial improvements, many inorganics such as heavy metals or hazardous organic toxic materials are released to the ...
    • An engineered genetic circuit for protein glycosylation in Escherichia coli 

      Bozkurt, Eray Ulaş (Bilkent University, 2021-05)
      Protein glycosylation is one of the most crucial and common post-translational modifications. Glycosylation provides certain advantages to host organisms and extend the proteome beyond genetic material. After the discovery ...
    • Engineering of probiotic Saccharomyces boulardii as a host for living therapeutic applications 

      Kurt, Orhan Nedim (Bilkent University, 2022-09)
      Therapeutic molecules or biologically active agents used in the treatments of disorders have been manufactured employing chemical synthesis methods with high costs and limited accessibility. Even though this approach to ...
    • Functional bacterial amyloid nanomaterials 

      Önür, Tuğçe (Bilkent University, 2016-09)
      Mis-folded or unfolded proteins tend to aggregate and aggregated structures are called as amyloids. Amyloid formation contributes to some human diseases and resulting in death in some cases. On the other hand, functional ...
    • Functionalized biofilm proteins for antibiotic degradation and SARS-CoV-2 capture 

      Özkul, Gökçe (Bilkent University, 2021-09)
      Among biomaterials, biofilm proteins occupy a great portion. They have many prominent properties such as mechanical strength, ability to be modified genetically and their stability against harsh physical and chemical ...
    • Genetically programmed engineered cells for biomaterials synthesis 

      Kırpat, Büşra Merve (Bilkent University, 2021-01)
      Several organisms can process nanomaterials and producing in various sizes and morphologies in mild conditions by utilizing specific proteins. In sea sponges, silicatein proteins play a key role in synthesizing silica ...
    • Glycosylation: a tool for engineering protein based materials 

      Işılak, Musa Efe (Bilkent University, 2019-09)
      Biofilms are bacterial communities formed by adhesion of cells to each other via extracellular matrix. Proteins, one of the components of biofilm matrix, can form fibers and have properties enabling their use as materials. ...
    • Microbial amyloids as functional biomaterials 

      Kehribar, Ebru Şahin (Bilkent University, 2021-01)
      Amyloids are fibrillar aggregations of proteins, dominated by β-sheets in the structure. Although amyloids are historically associated with disorders, they emerged as outstanding biomaterials due to their high mechanical ...
    • Multiplexed cell-based diagnostic devices for the detection of kidney disease pathological markers 

      Köse, Sıla (Bilkent University, 2020-12)
      Development of accurate, inexpensive and fast-screening devices has been a big vacancy in the field of medical diagnostics. Close monitoring and diagnosis of various diseases are generally conducted by typical analytical ...
    • Peptide based ligand discovery to prevent protein aggregation in neurodegenerative disease conditions 

      Beğli, Özge (Bilkent University, 2019-09)
      Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease are cognitively and physically debilitating and progressive diseases due to the gradual and irreversible loss of discrete ...
    • Peptide drug candidates for pathogenic amyloids 

      Özçelik, Cemile Elif (Bilkent University, 2020-01)
      Amyloid fibrils are very stable, ordered cross-β structured, resistant to protease degradation, proteinaceous composits. All amyloids have different peptide/protein sequences although they express similar structural ...
    • Peptide therapeutics to prevent protein aggregation in Huntington’s disease 

      Khan, Anooshay (Bilkent University, 2022-09)
      Huntington’s disease is a progressive, autosomal dominant neurodegenerative disease caused by dramatic CAG repeat expansion in exon 1 of the Huntington (HTT) gene. More than 36 CAG repeats lead to the generation of mutant ...
    • A self-actuated cellular protein delivery machinery 

      Ahan, Recep Erdem (Bilkent University, 2018-08)
      Owing to increase the knowledge on biology and available tools for genetic manipulations, biological systems are engineered to perform complex tasks. They can be designed to degrade toxic molecules in environment, produce ...
    • A synthetic biology approach for engineered functional biofilm 

      Kalyoncu, Ebuzer (Bilkent University, 2017-12)
      Extracellular polymeric substances consist of molecules, DNAs, carbohydrates, and proteins that are secreted by microbial biofilms. These molecules assist in the synthesis of bacterial biofilms as highly ordered, complex ...
    • A synthetic biology approach for nanomaterial design, synthesis and functionalization 

      Ölmez, Tolga Tarkan (Bilkent University, 2017-11)
      Biological formation of inorganic material occurs in most organisms in nature. Various biomolecules such as polypeptides, lipids and metabolites are responsible for biomineralization in cells and tissues. Biological synthesis ...
    • Synthetic biology approach for point-of-care device applications of biosensors 

      Köksaldı, İlkay Çisil (Bilkent University, 2021-09)
      Synthetic biology has broadened the scope of detection tool alternatives, among which whole-cell biosensors and cell-free programmable riboregulators are straightforward, inexpensive to develop and easily implementable to ...
    • Synthetic cellular systems for whole cell biocatalysis 

      Apaydın, Onur (Bilkent University, 2017-09)
      Synthetic biology is a field utilizing basic science and engineering approaches to create novel synthetic systems. Biocatalysis is one of those already existing processes which was reviewed intensely due to its advantages ...
    • Synthetic genetic circuits to monitor nanomaterial triggered toxicity 

      Saltepe, Behide (Bilkent University, 2020-07)
      In the past decades, nanomaterial (NM) usage in various fields has been of great interest because of their unique properties that show tuneable optical and physical properties depending on their size. Yet, safety ...