Browsing by Keywords "Peptides"
Now showing items 21-40 of 42
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Hierarchical self-assembly of histidine-functionalized peptide amphiphiles into supramolecular chiral nanostructures
(American Chemical Society, 2017)Controlling the hierarchical organization of self-assembling peptide amphiphiles into supramolecular nanostructures opens up the possibility of developing biocompatible functional supramolecular materials for various ... -
Identification of novel neutralizing single-chain antibodies against vascular endothelial growth factor receptor 2
(2011)Human vascular endothelial growth factor (VEGF) and its receptor (VEGFR-2/kinase domain receptor [KDR]) play a crucial role in angiogenesis, which makes the VEGFR-2 signaling pathway a major target for therapeutic applications. ... -
Inhibition of VEGF mediated corneal neovascularization by anti-angiogenic peptide nanofibers
(Elsevier, 2016-11)Atypical angiogenesis is one of the major symptoms of severe eye diseases, including corneal neovascularization, and the complex nature of abnormal vascularization requires targeted methods with high biocompatibility. The ... -
Investigating the effects of bioactive peptide nanofibers on the growth and differentiation behaviour of nervous system cells
(Bilkent University, 2017-07)Peripheral nerve regeneration is a tightly regulated process that entails the degeneration, proliferation, alignment and remyelination of Schwann cells. Tuning the bioactivity is important to support all of these processes ... -
Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gels
(Royal Society of Chemistry, 2017)Peptide amphiphiles (PAs) self-assemble into supramolecular nanofiber gels that provide a suitable environment for encapsulation of both hydrophobic and hydrophilic molecules. The PA gels have significant advantages for ... -
Materials for articular cartilage regeneration
(Bentham Science Publishers B.V., 2012)Many health problems remaining to be untreatable throughout the human history can be overcome by utilizing new biomedical materials. Healing cartilage defects is one of the problems causing significant health issue due to ... -
Multi-material specific, targeted self-assembly of nanocrystal emitters using genetically engineered peptides on optoelectronic microchips
(IEEE, 2008-11)We demonstrated material-specific binding of the quantum dot emitters hybridized with GEPI on multi-material patterned microchips. These proof-of-concept results open up new opportunities in nanophotonics, allowing for ... -
Nanoengineering hybrid supramolecular multilayered biomaterials using polysaccharides and self-assembling peptide amphiphiles
(Wiley-VCH Verlag, 2017)Developing complex supramolecular biomaterials through highly dynamic and reversible noncovalent interactions has attracted great attention from the scientific community aiming key biomedical and biotechnological applications, ... -
Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action
(Wiley-VCH Verlag, 2014)Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high ... -
Noncovalent functionalization of mesoporous silica nanoparticles with amphiphilic peptides
(Royal Society of Chemistry, 2014)The surface of mesoporous silica nanoparticles (MSNs) has been modified for enhancing their cellular uptake, cell targeting, bioimaging, and controlled drug release. For this purpose, covalent anchorage on the silica surface ... -
One-dimensional peptide nanostructure templated growth of iron phosphate nanostructures for lithium-ion battery cathodes
(American Chemical Society, 2016-06)Template-directed synthesis of nanomaterials can provide benefits such as small crystalline size, high surface area, large surface-to-volume ratio, and structural stability. These properties are important for shorter ... -
Peptide functionalized superparamagnetic iron oxide nanoparticles as MRI contrast agents
(The Royal Society of Chemistry, 2011)Magnetic resonance imaging (MRI) attracts great attention in cellular and molecular imaging due to its non-invasive and multidimensional tomographic capabilities. Development of new contrast agents is necessary to enhance ... -
Presentation of functional groups on self-assembled supramolecular peptide nanofibers mimicking glycosaminoglycans for directed mesenchymal stem cell differentiation
(Royal Society of Chemistry, 2017)Organizational complexity and functional diversity of the extracellular matrix regulate cellular behaviors. The extracellular matrix is composed of various proteins in the form of proteoglycans, glycoproteins, and nanofibers ... -
Sciatic nerve regeneration induced by glycosaminoglycan and laminin mimetic peptide nanofiber gels
(Royal Society of Chemistry, 2016)In the USA, 20 million patients suffer from neuropathy caused by peripheral nerve injuries, which costs approximately 150 billion annually. For longer nerve gaps and multiple injury sites, it is essential to use nerve ... -
Secondary structure prediction of beta-hairpin peptide tryptophan zipper-I
(2008)We have investigated the folding properties of tryptophan zipper-I molecule which folds into a stable β-hairpin motif in aqueous solution as suggested by nuclear magnetic resonance (NMR) experiments. An all-atom presentation, ... -
Self-assembled peptide nanofiber templated ALD growth of TiO2 and ZnO semiconductor nanonetworks
(Wiley - V C H Verlag GmbH & Co. KGaA, 2016)Here peptide amphiphile (PA) nanofiber network is exploited as a three‐dimensional soft template to construct anatase TiO2 and wurtzite ZnO nanonetworks. Atomic layer deposition (ALD) technique is used to coat the organic ... -
Self-assembled peptide nanostructures for functional materials
(Institute of Physics Publishing, 2016)Nature is an important inspirational source for scientists, and presents complex and elegant examples of adaptive and intelligent systems created by self-assembly. Significant effort has been devoted to understanding these ... -
Self-assembled proteins and peptides as scaffolds for tissue regeneration
(Wiley-VCH Verlag, 2015)Self-assembling proteins and peptides are increasingly gaining interest for potential use as scaffolds in tissue engineering applications. They self-organize from basic building blocks under mild conditions into supramolecular ... -
Supramolecular GAG-like self-assembled glycopeptide nanofibers Induce chondrogenesis and cartilage regeneration
(American Chemical Society, 2016)Glycosaminoglycans (GAGs) and glycoproteins are vital components of the extracellular matrix, directing cell proliferation, differentiation, and migration and tissue homeostasis. Here, we demonstrate supramolecular GAG-like ... -
Supramolecular nanostructure formation of coassembled amyloid inspired peptides
(American Chemical Society, 2016-06)Characterization of amyloid-like aggregates through converging approaches can yield deeper understanding of their complex self-assembly mechanisms and the nature of their strong mechanical stability, which may in turn ...
