Browsing by Keywords "DNA"
Now showing items 21-40 of 40
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Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis
(John Wiley & Sons, Inc., 2009)Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a ... -
Inferring phylogenetical tree by using hierarchical self organizing maps
(Bilkent University, 2002)In biology, inferring phylogenetical tree is an attempt to describe the evolutionary history of today’s species with the aim of finding their common ancestors. Specifically in molecular biology, it is used in understanding ... -
Investigation and comparison of the preprocessing algorithms for microarray analysis for robust gene expression calculation and performance analysis of technical replicates
(IEEE, 2006)Preprocessing of microarray data involves the necessary steps of background correction, normalization and summarization of the raw intensity data obtained from cDNA or oligo-arrays before statistical analysis. Several ... -
Ionic current inversion in pressure-driven polymer translocation through nanopores
(American Physical Society, 2015)We predict streaming current inversion with multivalent counterions in hydrodynamically driven polymer translocation events from a correlation-corrected charge transport theory including charge fluctuations around mean-field ... -
Like-Charge Attraction And Opposite-Charge Decomplexation Between Polymers and DNA Molecules
(American Physical Society, 2017)We scrutinize the effect of polyvalent ions on polymer-DNA interactions. We extend a recently developed test-charge theory [S. Buyukdagli, Phys. Rev. E 94, 042502 (2016)1539-375510.1103/PhysRevE.94.042502] to the case of ... -
Mammalian telomeric DNA suppresses endotoxin-induced uveitis
(American Society for Biochemistry and Molecular Biology Inc., 2010)Telomeric regions of mammalian chromosomes contain suppressive TTAGGG motifs that inhibit several proinflammatory and Th1-biased immune responses. Synthetic oligodeoxynucleotides (ODN) expressing suppressive motifs can ... -
Multiplex systems for the amplification of short tandem repeat loci: evaluation of laser fluorescence detection
(1997)Short tandem repeat (STR) loci are ideal markers for personal identification and for genomic mapping. Two fluorescent multiplex systems, each designed for simultaneous PCR amplification of four polymorphic STR loci (HUMCSF1PO, ... -
Muscle Hemangiomatosis presenting as a severe feature in a patient with the pten mutation: Expanding the phenotype of vascular malformations in bannayan-riley-ruvalcaba syndrome
(2012)Bannayan-Riley-Ruvalcaba syndrome (BRRS) is a rare autosomal, dominantly-inherited, hamartoma syndrome with distinct phenotypic features. Mutations in the PTEN gene have been identified in PTEN hamartoma tumor syndromes. ... -
Non-intercalative, deoxyribose binding of boric acid to calf thymus DNA
(Springer, 2014)The present study characterizes the effects of the boric acid binding on calf thymus DNA (ct-DNA) by spectroscopic and calorimetric methods. UV-Vis absorbance spectroscopy, circular dichroism (CD) spectroscopy, transmission ... -
Oligonucleotide-based label-free detection with optical microresonators: strategies and challenges
(Royal Society of Chemistry, 2016)This review targets diversified oligonucleotide-based biodetection techniques, focusing on the use of microresonators of whispering gallery mode (WGM) type as optical biosensors mostly integrated with lab-on-a-chip systems. ... -
On genomic repeats and reproducibility
(Oxford University Press, 2016)Results: Here, we present a comprehensive analysis on the reproducibility of computational characterization of genomic variants using high throughput sequencing data. We reanalyzed the same datasets twice, using the same ... -
Privacy-preserving genomic testing in the clinic: a model using HIV treatment
(Nature Publishing Group, 2016)Purpose:The implementation of genomic-based medicine is hindered by unresolved questions regarding data privacy and delivery of interpreted results to health-care practitioners. We used DNA-based prediction of HIV-related ... -
Production and structural characterization of biosurfactant produced by newly isolated staphylococcus xylosus STF1 from petroleum contaminated soil
(Elsevier BV, 2015)Petroleum-contaminated soil was used to isolate and characterize biosurfactant producing bacteria. The strain could produce higher amount of biosurfactant in medium supplemented with motor oil as sole source of carbon and ... -
Real-time and selective detection of single nucleotide DNA mutations using surface engineered microtoroids
(American Chemical Society, 2015)Mictoroids, as optical biosensors, can provide beneficial biosensing platforms to understand DNA alterations. These alterations could have significant clinical importance, such as the case of Pseudomonas aeruginosa, which ... -
SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer
(National Academy of Sciences, 2009)The epithelial-mesenchymal transition (EMT) contributes to cancer metastasis. Two ZEB family members, ZEB1 and ZEB2(SIP1), inhibit transcription of the E-cadherin gene and induce EMT in vitro. However, their relevance to ... -
Skewed X chromosome inactivation in blood cells of women with scleroderma
(John Wiley & Sons, Inc., 2005)Objective. Scleroderma (SSc) is an autoimmune disease of unknown etiology. The disease is 3-8 times more frequent in women than in men. The role of X chromosome inactivation (XCI) in the predisposition of women to autoimmunity ... -
Skewed X-chromosome inactivation in scleroderma
(Springer New York, 2008)Scleroderma is a female-prevalent autoimmune disease of unclear etiology. Two fundamental gender differences, skewed X-chromosome inactivation (XCI) and pregnancy-related microchimerism, have been implicated in scleroderma. ... -
Spectroscopic evaluation of DNA–borate Interactions
(Humana Press Inc., 2015)We describe the binding characteristics of two natural borates (colemanite and ulexite) to calf thymus DNA by UV–vis absorbance spectroscopy, circular dichroism (CD) spectroscopy, Fourier transform infrared (FT-IR) ... -
Synthesis of silica-based nanomaterials and their applications in fluorescent, biological and chemical sensing
(Bilkent University, 2018-06)This thesis describes development of nanoparticle-based liquid sensors and coatings for droplet-based bioassays. Liquid sensors were produced from mesostructured (2-50 nm) hybrid silica nanoparticles. Detection of trace ... -
Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa
(BioMed Central Ltd., 2014-11-07)Background: Turkey is a crossroads of major population movements throughout history and has been a hotspot of cultural interactions. Several studies have investigated the complex population history of Turkey through a ...
