Zhang, Q.Liu, Z.Moncada-Velez, M.Chen, J.Ogishi, M.Bigio, B.Yang, R.Arias, A. A.Zhou, Q.Han, J. E.Özçelik, TayfunUğurbil, A. C.Zhang, P.Rapaport, F.Li, J.Spaan, A. N.2021-03-052021-03-0520200036-8075http://hdl.handle.net/11693/75852Clinical outcomes of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (COVID-19). Epidemiological studies have identified three risk factors for severe disease: being male, being elderly, and having other medical conditions. However, interindividual clinical variability remains huge in each demographic category. Discovering the root cause and detailed molecular, cellular, and tissue- and body-levelmechanismsunderlying life-threatening COVID-19 is of the utmost biological and medical importance.EnglishArticle10.1126/science.abd45701095-9203