Vural, B.Şehitoğlu, E.Çavuş, F.Yalçınkaya, N.Haytural, H.Küçükerden, M.Ulusoy, C.Uğurel, E.Turan, S.Bulut, L.Türkoğlu, R.Shugaiv, E.Kürtüncü, M.Atakan, S.Güre, A. O.Gül, A.Eraksoy, M.Demir, G. A.Tüzün, E.2016-02-082016-02-0820130165-5728http://hdl.handle.net/11693/20761Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. © 2013 Elsevier B.V.EnglishBehçet's diseaseNeuro-Behçet's diseaseAnti-neuronal antibodyMitochondrial carrier homolog 1AntibodyAutoimmunityArticle10.1016/j.jneuroim.2013.08.0071872-8421