Cankara-Pirol, Ş.Çalışkan, B.Durmaz, İremAtalay, RengülBanoğlu, E.2016-02-082016-02-0820140223-5234http://hdl.handle.net/11693/24936We synthesized a series of novel amide derivatives of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid and assessed their antiproliferative activities against three human cancer cell lines (Huh7, human liver; MCF7, breast and HCT116, colon carcinoma cell lines) with the sulforhodamine B assay. Compound 4j with 2-chloro-4-pyridinyl group in the amide part exhibited promising cytotoxic activity against all cell lines with IC<inf>50</inf>values of 1.6 μM, 3.3 μM and 1.1 μM for Huh7, MCF7 and HCT116 cells, respectively, and produced dramatic cell cycle arrest at SubG1/G1 phase as an indicator of apoptotic cell death induction. On the basis of their high potency in cellular environment, these straightforward pyrazole-3-carboxamide derivatives may possess potential in the design of more potent compounds for intervention with cancer cell proliferation.EnglishApoptosisAutophagyCytotoxicityDiarylpyrazoleQuinolineG1 phaseArticle10.1016/j.ejmech.2014.09.056