Alici, K. B.2016-02-082016-02-0820141536-125Xhttp://hdl.handle.net/11693/26321We present spectral hybridization of organic and inorganic resonant materials and related bio-sensing mechanism. We utilized a bound protein (streptavidin) and a Fano-resonant metasurface to illustrate the concept. The technique allows us to investigate the vibrational modes of the streptavidin and how they couple to the underlying metasurface. This optical, label-free, nonperturbative technique is supported by a coupled mode-theory analysis that provides information on the structure and orientation of bound proteins. We can also simultaneously monitor the binding of analytes to the surface through monitoring the shift of the metasurface resonance. All of this data opens up interesting opportunities for applications in biosensing, molecular electronics and proteomics. © 2014 IEEE.EnglishAvidinBiosensorBiotinCollective excitationEnhancement factorFano resonanceMetamaterialMicroscopyMonolayerNanoantennaNear-field effectsSelf-assemblySpectroscopyStreptavidinSurface plasmonSurface-enhanced infrared absorption (SEIRA)Temporal-coupled mode theoryThin filmsAvidinBiotinCollective excitationsEnhancement factorFano resonancesMode theoryNano antennasNear field effectStreptavidinSurface plasmonsSurface-enhanced infrared absorptionsBiosensorsLight absorptionMetamaterialsMicroscopic examinationMolecular biologyMonolayersResonanceSelf assemblySpectroscopyThin filmsProteinsArticle10.1109/TNANO.2013.2296896