Detecting secondary structure and surface orientation of helical peptide monolayers from resonant hybridization signals

Alici, K. B.Gallardo I.F.2016-02-082016-02-08201320452322http://hdl.handle.net/11693/20760Hybridization of dominant vibrational modes with meta-surface resonance allows detection of both structural changes and surface orientations of bound helical peptides. Depending on the resonance frequency of meta-molecules, a red- or blue- shift in peptide Amide-I frequency is observed. The underlying coupling mechanism is described by using a temporal coupled mode theory that is in very good agreement with the experimental results. This hybridization phenomenon constitutes the basis of many nanophotonic systems such as tunable coupled mode bio-sensors and dynamic peptide systems driven by infrared signals.Englishamidepeptidealgorithmarticleatomic force microscopychemical structurechemistryinfrared spectrophotometryprotein secondary structureAlgorithmsAmidesMicroscopy, Atomic ForceModels, MolecularPeptidesProtein Structure, SecondarySpectrophotometry, InfraredDetecting secondary structure and surface orientation of helical peptide monolayers from resonant hybridization signalsArticle10.1038/srep02956