Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

Demir, Z.Guven, E.B.Ozbey, S.Kazak, C.Atalay, R.C.Tuncbilek, M.2016-02-082016-02-0820152235234http://hdl.handle.net/11693/22691Novel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC50 less than 1 1/4M.36 induces senescence associated cell death, which was demonstrated with SA2-Gal assay. © 2014 Elsevier Masson SAS.EnglishAdenineCytotoxic activityHepatocellular carcinomaPurine derivativesSenescenceantineoplastic agentpurinepurine derivativecell deathcell proliferationchemical structurechemistrydose responsedrug effectsdrug screeningHCT116 cell lineHepG2 cell linehumanstructure activity relationsynthesistumor cell cultureAntineoplastic AgentsCell DeathCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHCT116 CellsHep G2 CellsHumansModels, MolecularMolecular StructurePurinesStructure-Activity RelationshipTumor Cells, CulturedSynthesis of novel substituted purine derivatives and identification of the cell death mechanismArticle10.1016/j.ejmech.2014.10.080