Yavuz, MerveHınçer, AhmetSemerci, AslıŞeker, Urartu Özgür ŞafakŞeker, Urartu Özgür Şafak2025-02-282025-02-282024-11-189783111329482https://hdl.handle.net/11693/117011The engineered biological systems offer new avenues for precision medicine and therapeutic interventions. The development of biological devices for cellular targeting and decision-making executes synthetic biology tools to integrate computational logic and sensing capabilities in living cells. The machineries have the ability to detect specific biomarkers, process environmental signals, and perform targeted responses. In order to specifically recognize and destroy cancer cells, one of the crucial advancements resides in the design of chimeric antigen receptor T cells. The cells harbor synthetic genetic circuitries to sense external stimuli, the presence of a pathogen or a disease marker, and to give a cellular response. The biological devices are designed as robust and adaptive based on synthetic biology applications by leveraging modular and programmable genetic components. The efficacy and safety of cellular therapies are enhanced via precise cellular targeting and dynamic decision-making that provide promising approaches for diagnosing and treating a wide range of diseases and personalized medicine. © 2025 Walter de Gruyter GmbH, Berlin/Boston.EnglishCC BY 4.0 DEED (Attribution 4.0 International)https://creativecommons.org/licenses/by/4.0/Programming cellsCellular targetingBiological devicesMammalian cellsMicrobial cellsBook Chapter10.1515/9783111329499-0029783111329499