Canbolat, M. F.Celebioglu A.Uyar, Tamer2016-02-082016-02-0820140927-7765http://hdl.handle.net/11693/26315In this study, we select naproxen (NAP) as a reference drug and electrospun poly (e-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form inclusion complex (NAP-βCD-IC) and then NAP-βCD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-βCD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-βCD-IC and the presence of CD-IC in PCL/NAP-βCD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-βCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300. nm, in addition, the aggregates of CD-IC in PCL/NAP-βCD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-βCD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC.EnglishCyclodextrinDrugInclusion complexNanofibersNaproxenReleaseCyclodextrinsDrug deliveryPolycaprolactoneAverage fiber diametersDrugDrug-delivery systemsInclusion complexNaproxensPoly(ecaprolactone) (PCL)ReleaseSolubility enhancementNanofibersBeta cyclodextrinBufferNanofiberNaproxenPolycaprolactonePolycaprolactone nanofiberUnclassified drugBeta cyclodextrinBeta cyclodextrin derivativeNanofiberNaproxenPolycaprolactonePolyesterArticleComplex formationControlled studyDrug delivery systemDrug releaseDrug solubilityElectrospinningInfrared spectroscopyParticle sizePhysical chemistryPriority journalProton nuclear magnetic resonanceScanning electron microscopyThermogravimetryX ray diffractionChemistryHigh performance liquid chromatographyNuclear magnetic resonance spectroscopyProceduresSolubilityTissue engineeringUltrastructureUltraviolet spectrophotometryBeta-CyclodextrinsChromatography, High Pressure LiquidDrug Delivery SystemsMagnetic Resonance SpectroscopyNanofibersNaproxenPolyestersSolubilitySpectrophotometry, UltravioletSpectroscopy, Fourier Transform InfraredThermogravimetryTissue EngineeringX-Ray DiffractionArticle10.1016/j.colsurfb.2013.11.021