Khalily, M. A.Gulseren, G.Tekinay, A. B.Güler, Mustafa O.2016-02-082016-02-0820151043-1802http://hdl.handle.net/11693/25035Understanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal click reaction to label live cells. This biocompatible and biodegradable nanocatalyst was formed by self-assembled peptide nanofibers complexed with copper ions. The supramolecular nanocatalyst enhanced azide-alkyne cycloaddition reaction rate under physiological conditions and was shown to be useful for efficient bioorthogonal labeling of live cells.EnglishAlkyneAmphophileAzideCopper ionNanofiberArticleCell functionCell labelingChemical reactionClick chemistryControlled studyCycloadditionCytotoxicityNanocatalystSupramolecular chemistryArticle10.1021/acs.bioconjchem.5b00443