Özkan, MelisKeser, YağmurKoç, AhmetTuncel, Dönüş2020-02-242020-02-242019-101088-4246http://hdl.handle.net/11693/53487Porphyrin derivatives are highly attractive in the construction of multifunctional molecular platforms with interesting properties and applications. In this regard, we report here the use of a multifunctional porphyrin-based molecular platform as a photosensitizer for photodynamic therapy and as a drug carrier. This molecular platform was constructed by conjugating a host molecule, cucurbit[7]uril to a triglycosylated tetraphenyl porphyrin and serves very efficiently as a photosensitizer in the inactivation of both gram-negative (Escherichia coli, E. coli) and gram-positive bacteria (Bacillus subtilis, B. subtilis) and growth inhibition of cancer cells as well as a doxorubicin (DOX) carrier for chemo-photodynamic dual cancer therapy. Another remarkable feature of this photosensitizer is that it shows negligible cytotoxicity in the dark.EnglishPorphyrinCucurbiturilMulti-functional molecular platformLight-activated antimicrobial agentPhotodynamic effectDoxorubicin deliveryAnticancer therapyArticle10.1142/S1088424619501578