Selective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizers

Erbas-Cakmak, S.Cakmak, F. P.Topel, S. D.Uyar, T. B.Akkaya, E. U.2016-02-082016-02-0820151359-7345http://hdl.handle.net/11693/21347A series of pH and GSH responsive photosensitizers were designed and synthesized. pK<inf>a</inf> values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.EnglishpKaSelective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizersArticle10.1039/c5cc01261a1364-548X