Vural, B.Uğurel, E.Tüzün, E.Kürtüncü, M.Zuliani, L.Çavus, F.İçoz, S.Erdağ, E.Gül, A.Güre, A. O.Vincent, A.Özbek, U.Eraksoy, M.Demir, G. A.2015-07-282015-07-282011-10-280165-5728http://hdl.handle.net/11693/12155No disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD. © 2011 Elsevier B.V.EnglishBehçet's diseaseNeuro-Behçet's diseaseAnti-neuronal antibodyStress-induced-phosphoprotein 1AntibodyAutoimmunityArticle10.1016/j.jneuroim.2011.08.008