Gurdal, E. E.Yarim, M.Durmaz, I.Cetin Atalay, R.2016-02-082016-02-0820132194-9379http://hdl.handle.net/11693/21150This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4- benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50). © Georg Thieme Verlag KG Stuttgart · New York.EnglishBenzhydrylpiperazineBenzoyl chlorideCytotoxicitySulfonyl chlorideSulphorhodamine Bantineoplastic agentArticle10.1055/s-0032-1333275