Karaduman, AyşenurKaroğlu-Eravşar, Elif TuğçeKaya, UtkuAydın, AlazAdams, Michelle MarieKafalıgönül, Hulusi2024-03-192024-03-192023-06-100197-4580https://hdl.handle.net/11693/114992Various aspects of visual functioning, including motion perception, change with age. Yet, there is a lack of comprehensive understanding of age-related alterations at different stages of motion processing and in each motion system. To understand the effects of aging on second-order motion processing, we investigated optomotor responses (OMR) in younger and older wild-type (AB-strain) and acetylcholinesterase (achesb55/+) mutant zebrafish. The mutant fish with decreased levels of acetylcholinesterase have been shown to have delayed age-related cognitive decline. Compared to previous results on first-order motion, we found distinct changes in OMR to second-order motion. The polarity of OMR was dependent on age, such that second-order stimulation led to mainly negative OMR in the younger group while older zebrafish had positive responses. Hence, these findings revealed an overall aging effect on the detection of second-order motion. Moreover, neither the genotype of zebrafish nor the spatial frequency of motion significantly changed the response magnitude. Our findings support the view that age-related changes in motion detection depend on the activated motion system. © 2023 Elsevier Inc.enCC BY 4.0 Deed (Attribution 4.0 International)AcetylcholinesteraseAgingMotion detectionSecond-order motionZebrafishArticle10.1016/j.neurobiolaging.2023.06.005