Soner, Esra Deniz2016-04-292016-04-292015-092015-0901-10-2015http://hdl.handle.net/11693/29018Cataloged from PDF version of thesis.Includes bibliographical references (leaves 76-81).Thesis (M.S.): Bilkent University, Department of Physics, İhsan Doğramacı Bilkent University, 2015.In this work, the design, synthesis and characterization of fluorescent, water-soluble, multivalent glycoconjugates for their potential applications in active-targetted cellular theranostics through receptor-mediated endocytosis are presented. Gluco-functionalized thiophene monomers are utilized for the pre-functionalized Suzuki coupling polymerization of glycopolythiophenes and glycopolythiophenerotaxanes. The pre-functionalized glycopolythiophenerotaxane synthesis route was designed to provide in situ complexation between boronic ester thiophene monomer and water-soluble macrocycle cucurbit[7]uril, for the Suzuki coupling with the glycothiophene monomer in water. Red emitting oligomers carrying azide groups were utilized for the synthesis of post-functionalized glycoconjugate oligomers. These functionalizations were carried through 1,3-dipolar cycloaddition (click reaction) between azide groups and alkyne-functionalized monosaccharides (mannose or glucose). Structural and photophysical properties of glycopolythiophenes were investigated through ¹H-NMR, UV-VIS, and Fluorescence Spectroscopy. Monomers in synthetic steps were analysed through ¹H-NMR, IR, and ¹³C-NMR. Structural, photophysical and morphological properties of red oligomers were investigated through ¹H-NMR, HRMS-TOF, DLS, SEM.xv, 81 leaves : charts.Englishinfo:eu-repo/semantics/openAccessConjugated polymersGlycoconjugateCucurbiturilPolyrotaxaneClick reactionThesisB151603