Bayik D.Gursel, I.Klinman, D. M.2018-04-122018-04-1220161043-6618http://hdl.handle.net/11693/36789Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune system have been developed and are being widely studied in preclinical models. These agents vary in sequence, mechanism of action, and cellular target(s) but share the ability to suppress a plethora of inflammatory responses. This work reviews the types of immunosuppressive oligodeoxynucleotide (Sup ODN) and compares their therapeutic activity against diseases characterized by pathologic levels of immune stimulation ranging from autoimmunity to septic shock to cancer (see graphical abstract). The mechanism(s) underlying the efficacy of Sup ODN and the influence size, sequence and nucleotide backbone on function are considered. © Published by Elsevier Ltd.EnglishCpG oligonucleotideDendritic cellIRF5IRF8TLR9a 151CpG oligodeoxynucleotideQuanine oligodeoxynucleotideh 154Inhibitory oligodeoxynucleotideMicrosatellite oligodeoxynucleotideOligonucleotideSTAT proteinSuppressive oligodeoxynucleotideSynthetic oligonucleotideToll like receptor 4Toll like receptor 7Toll like receptor 9Unclassified drugArticle10.1016/j.phrs.2015.11.010