Aytac Z.Yildiz, Z. I.Kayaci-Senirmak, F.S. Keskin, N. O.Kusku, S. I.Durgun, EnginTekinay, T.Uyar, Tamer2018-04-122018-04-1220160021-8561http://hdl.handle.net/11693/36745We have proposed a new strategy for preparing free-standing nanofibrous webs from an inclusion complex (IC) of a well-known flavor/fragrance compound (limonene) with three modified cyclodextrins (HPβCD, MβCD, and HPγCD) via electrospinning (CD/limonene-IC-NFs) without using a polymeric matrix. The experimental and computational modeling studies proved that the stoichiometry of the complexes was 1:1 for CD/limonene systems. MβCD/limonene-IC-NF released much more limonene at 37, 50, and 75 °C than HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF because of the greater amount of preserved limonene. Moreover, MβCD/limonene-IC-NF has released only 25% (w/w) of its limonene, whereas HPβCD/limonene-IC-NF and HPγCD/limonene-IC-NF released 51 and 88% (w/w) of their limonene in 100 days, respectively. CD/limonene-IC-NFs exhibited high antibacterial activity against E. coli and S. aureus. The water solubility of limonene increased significantly and CD/limonene-IC-NFs were dissolved in water in a few seconds. In brief, CD/limonene-IC-NFs with fast-dissolving character enhanced the thermal stability and prolonged the shelf life along with antibacterial properties could be quite applicable in food and oral care applications.EnglishAntibacterial activityComputational modelingElectrospinningEssential oilModified cyclodextrinsComputation theoryCyclodextrinsElectrospinningEscherichia coliEssential oilsFlavor compoundsMonoterpenesNanofibersOils and fatsPolymersSpinning (fibers)Anti-bacterial activityAntibacterial propertiesComputational modelInclusion complexModified cyclodextrinsPolymeric matricesProlonged releaseWater solubilitiesDissolutionAntiinfective agentCyclodextrinCyclohexene derivativeDrug carrierEssential oilLimoneneNanofiberTerpeneChemistryDrug effectsDrug releaseDrug stabilityEscherichia coliMolecular computerNuclear magnetic resonance spectroscopyParticle sizeScanning electron microscopySolubilityStaphylococcus aureusThermogravimetryX ray crystallographyAnti-Bacterial AgentsComputers, MolecularCrystallography, X-RayCyclodextrinsCyclohexenesDrug CarriersDrug LiberationDrug StabilityEscherichia coliMagnetic Resonance SpectroscopyMicroscopy, Electron, ScanningNanofibersOils, VolatileParticle SizeSolubilityStaphylococcus aureusTerpenesThermogravimetryArticle10.1021/acs.jafc.6b02632