Bousquet, J.Anto, J. M.Sterk, P. J.Adcock, I. M.Chung, K. F.Roca, J.Agusti, A.Brightling, C.Cambon-Thomsen, A.Cesario, A.Abdelhak, S.Antonarakis, S. E.Avignon, A.Ballabio, A.Baraldi, E.Baranov, A.Bieber, T.Bockaert, J.Brahmachari, S.Brambilla, C.Bringer, J.Dauzat, M.Ernberg, I.Fabbri, L.Frogue, P.Galas, D.Gojobori2, T.Hunter, P.Jorgensen, C.Kauffmann, F.Kourilsky, P.Kowalski, M. L.Lancet, D.Le Pen, C.Mallet, J.Mayosi, B.Mercier, J.Metspalu, A.Nadeau, J. H.Ninot, G.Noble, D.Öztürk, M.Palkonen, S.Préfaut, C.Rabe, K.Renard, E.Roberts, R. G.Samolinski, B.Schünemann, H. J.Simon, H. U.Soares, M. B.Superti-Furga, G.Tegner, J.Verjovski-Almeida, S.Wellstead, P.Wolkenhauer, O.Wouters, E.Balling, R.Brookes, A. J.Charron, D.Pison, C.Chen, Z.Hood, L.Auffray, C.2019-02-112019-02-112011http://hdl.handle.net/11693/49237We propose an innovative, integrated, cost-e ective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multilevel systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-speci c complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and speci cities of local economies and health systems.EnglishArticle10.1186/gm2591756-994X