Liman, MenekşeTürkmen, Yunus Emre2019-02-212019-02-2120180040-4039 (print)1873-3581 (online)http://hdl.handle.net/11693/49958An efficient one-pot synthetic methodology has been developed for the benzylic amination reactions of methyl-substituted azine N-oxides that operate under mild conditions. The reaction was found to tolerate quinoline and isoquinoline N-oxides with electron donating and withdrawing substituents as the electrophilic reaction partners as well as a broad range of nucleophilic primary, secondary and aromatic amines, affording the benzylic amination products in up to 82% yield.EnglishAminesAzine N-oxidesBenzylic aminationHeteroaromatic compoundsOne-pot synthesisArticle10.1016/j.tetlet.2018.03.062