Uz, E.Dolen, I.Al, A. R.Ozcelik, T.2015-07-282015-07-282007-030340-6717http://hdl.handle.net/11693/11566Pre-eclampsia is a disorder that affects approximately 5% of pregnancies. We tested the hypothesis that skewed X-chromosome inactivation (XCI) could be involved in the pathogenesis of pre-eclampsia. Peripheral blood DNA was obtained from 67 pre-eclampsia patients and 130 control women. Androgen receptor (AR) was analyzed by the Hpa II/polymerase chain reaction assay to assess XCI patterns in DNA extracted from peripheral-blood cells. In addition, buccal cells were obtained from seven patients, and the analysis repeated. Extremely skewed XCI was observed in 10 of 46 informative patients (21.74%), and in 2 of 86 informative controls (2.33%, P = 0.0005; χ2 test). Our findings support a role for the X-chromosome in the pathogenesis of pre-eclampsia in a subgroup of patients.EnglishRecurrent Spontaneous-abortionGenome-wide ScanFemale PredispositionHigh-frequencyWomenAutoimmunePatternsDiseaseSelectionRatiosArticle10.1007/s00439-006-0281-3