Gül, A.Özbek, U.Öztürk, C.Inanç, M.Koniçe, M.Özçelik, T.2016-02-082016-02-0819960263-7103http://hdl.handle.net/11693/25699We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behcet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.EnglishActivated protein C resistanceBehcet's diseaseDeep vein thrombosisFactor V gene mutationVasculitisActivated protein cBlood clotting factor 5AdolescentAdultControlled studyDeep vein thrombosisGene frequencyGene mutationHumanMajor clinical studyPriority journalVein thrombosisBehcet syndromeFactor VFemaleHeterozygoteHumansMaleMiddle agedMutationRisk factorsThrombophlebitisArticle