Okan, M.Balci, O.Kocabas, C.2016-02-082016-02-0820110925-4005http://hdl.handle.net/11693/21655A new type of differential surface plasmon (SPR) sensor integrated with a microfluidic system is presented. The working principle of the microfluidic device is based on hydrodynamic modulation of two laminar streams inside a microchannel to provide periodic changes of the environment on the SPR sensor. The modulated reflectance is then demodulated using a lock-in amplifier. The presented sensor provides sensitivities of index of refraction about 4 × 10-8 RIU together with a 4 orders of magnitude dynamic range. This method demonstrates a sensitive detection scheme which could be used for label-free detection. © 2011 Elsevier B.V. All rights reserved.EnglishSurface plasmon resonance sensorPhase sensitive detectionLab-on-a-chip systemsMicrofluidic devicesOptical sensorsArticle10.1016/j.snb.2011.08.0461873-3077