Lanin, A.Fedotov, I. V.Sidorov Biryukov, D. S.Doronina Amitonova, L. V.Ivashkina, O. I.Zots, M. A.Sun, C. K.Ilday, F. O.Fedotov, A. B.Anokhin, K. V.Zheltikov, A. M.2015-07-282015-07-282012-03-060003-6951http://hdl.handle.net/11693/13222Large-core hollow photonic- crystal fibers (PCFs) are shown to enable a fiber-format air-guided delivery of ultrashort infrared laser pulses for neurosurgery and nonlinear-optical imaging. With an appropriate dispersion precompensation, an anomalously dispersive 15-mu m-core hollow PCF compresses 510-fs, 1070-nm light pulses to a pulse width of about 110 fs, providing a peak power in excess of 5 MW. The compressed PCF output is employed to induce a local photodisruption of corpus callosum tissues in mouse brain and is used to generate the third harmonic in brain tissues, which is captured by the PCF and delivered to a detector through the PCF cladding.EnglishPicosecond pulsesSoliton outputMicroscopyBreakdownArticle10.1063/1.3681777