Turan, I. S.Cakmak, F. P.Yildirim, D. C.Cetin Atalay, R.Akkaya, E. U.2016-02-082016-02-0820140947-6539http://hdl.handle.net/11693/26369Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.EnglishBODIPY dyesPhotochemistryPhotodynamic actionPhotosensitizersSinglet oxygenCell cultureDissolved oxygenMolecular oxygenPeptidesPhotochemical reactionsPhotodynamic therapyBodipy dyesCancer cellsCytotoxicGlutathione concentrationGlutathionesNear-IRPhotodynamic actionSinglet oxygenPhotosensitizersArticle10.1002/chem.2014054501521-3765