Celebioglu A.Umu, O. C. O.Tekinay, T.Uyar, Tamer2016-02-082016-02-0820140927-7765http://hdl.handle.net/11693/26291The electrospinning of nanofibers (NF) from cyclodextrin inclusion complexes (CD-IC) with an antibacterial agent (triclosan) was achieved without using any carrier polymeric matrix. Polymer-free triclosan/CD-IC NF were electrospun from highly concentrated (160% CD, w/w) aqueous triclosan/CD-IC suspension by using two types of chemically modified CD; hydroxypropyl-beta-cyclodextrin (HPβCD) and hydroxypropyl-gamma-cyclodextrin (HPγCD). The morphological characterization of the electrospun triclosan/CD-IC NF by SEM elucidated that the triclosan/HPβCD-IC NF and triclosan/HPγCD-IC NF were bead-free having average fiber diameter of 520±250nm and 1100±660nm, respectively. The presence of triclosan and the formation of triclosan/CD-IC within the fiber structure were confirmed by 1H-NMR, FTIR, XRD, DSC, and TGA studies. The initial 1:1molar ratio of the triclosan:CD was kept for triclosan/HPβCD-IC NF after the electrospinning and whereas 0.7:1molar ratio was observed for triclosan/HPγCD-IC NF and some uncomplexed triclosan was detected suggesting that the complexation efficiency of triclosan with HPγCD was lower than that of HPβCD. The antibacterial properties of triclosan/CD-IC NF were tested against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. It was observed that triclosan/HPβCD-IC NF and triclosan/HPγCD-IC NF showed better antibacterial activity against both bacteria compared to uncomplexed pure triclosan.EnglishAntibacterial activityCyclodextrinElectrospinningInclusion complexNanofibersTriclosanBacteriaCyclodextrinsElectrospinningEscherichia coliSuspensions (fluids)Anti-bacterial activityAntibacterial propertiesAverage fiber diametersCyclodextrin inclusion complexesElectrospun nanofibersInclusion complexMorphological characterizationTriclosanNanofibers2 hydroxypropyl beta cyclodextrinCyclodextrinHydroxypropyl gamma cyclodextrinNanofiberTriclosanTriclosan hydroxypropyl beta cyclodextrinTriclosan hydroxypropyl gamma cyclodextrinUnclassified drugAntiinfective agentCyclodextrinNanofiberTriclosanAbsorptionAntibacterial activityArticleChemical compositionChemical structureComparative studyConcentration (parameters)ConductanceElectrospinningEscherichia coliFiber diameterMorphologyNonhumanPhysical parametersPriority journalStaphylococcus aureusSurface propertyviscosityChemistryDrug effectsElectric conductivityElectrodeMicrobial sensitivity testParticle sizeSynthesisEscherichia coliNegibacteriaPosibacteriaStaphylococcus aureusAnti-Bacterial AgentsCyclodextrinsElectric ConductivityElectrodesEscherichia coliMicrobial Sensitivity TestsMolecular StructureNanofibersParticle SizeStaphylococcus aureusSurface PropertiesTriclosanViscosityAntibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexesArticle10.1016/j.colsurfb.2013.10.029