Celebioglu A.Aytac Z.Umu, O. C. O.Dana, A.Tekinay, T.Uyar, Tamer2016-02-082016-02-0820140144-8617http://hdl.handle.net/11693/26482One-step synthesis of size-tunable silver nanoparticles (Ag-NP) incorporated into electrospun nanofibers was achieved. Initially, in situ reduction of silver salt (AgNO3) to Ag-NP was carried out in aqueous solution of polyvinyl alcohol (PVA). Here, PVA was used as reducing agent and stabilizing polymer as well as electrospinning polymeric matrix for the fabrication of PVA/Ag-NP nanofibers. Afterwards, hydroxypropyl-beta-cyclodextrin (HPβCD) was used as an additional reducing and stabilizing agent in order to control size and uniform dispersion of Ag-NP. The size of Ag-NP was ∼8 nm and some Ag-NP aggregates were observed for PVA/Ag-NP nanofibers, conversely, the size of Ag-NP decreased from ∼8 nm down to ∼2 nm within the fiber matrix without aggregation were attained for PVA/HPβCD nanofibers. The PVA/Ag-NP and PVA/HPβCD/Ag-NP nanofibers exhibited surface enhanced Raman scattering (SERS) effect. Moreover, antibacterial properties of PVA/Ag-NP and PVA/HPβCD/Ag-NP nanofibrous mats were tested against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria.EnglishCyclodextrinElectrospinningNanofibersPolyvinyl alcohol (PVA)Silver nanoparticles (Ag-NP)Antibacterial propertiesElectrospun nanofibersPoly (vinyl alcohol) (PVA)Silver nanoparticlesStabilizing agentsStaphylococcus aureusSurface enhanced Raman Scattering (SERS)Uniform dispersionsBacteriaCyclodextrinsElectrospinningEscherichia coliNanofibersNanoparticlesPolyvinyl alcoholsSurface scatteringSilverBacteria (microorganisms)Escherichia coliNegibacteriaPosibacteriaStaphylococcus aureus2 hydroxypropyl beta cyclodextrin2-hydroxypropyl-beta-cyclodextrinAntiinfective agentBeta cyclodextrin derivativeCyclodextrinMetal nanoparticleNanofiberPolyvinyl alcoholSilverArticleChemistryDrug effectElectrochemical analysisElectrospinningEscherichia coliGrowth, development and agingOxidation reduction reactionParticle sizePolyvinyl alcohol (PVA)Raman spectrometryscanning electron microscopySilver nanoparticles (Ag-NP)Staphylococcus aureusSurface propertyUltrastructureCyclodextrinElectrospinningNanofibersPolyvinyl alcohol (PVA)Silver nanoparticles (Ag-NP)Anti-Bacterial AgentsBeta-CyclodextrinsElectrochemical TechniquesEscherichia coliMetal NanoparticlesMicroscopy, Electron, ScanningNanofibersOxidation-ReductionParticle SizePolyvinyl AlcoholSilverSpectrum Analysis, RamanStaphylococcus aureusSurface PropertiesArticle10.1016/j.carbpol.2013.08.097