Gurdal, E.E.Durmaz I.Cetin-Atalay, R.Yarim, M.2016-02-082016-02-08201514756366http://hdl.handle.net/11693/21381Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Based on the GI<inf>50</inf> values of the compounds, most of the benzothiazole-piperazine derivatives are active against HUH-7, MCF-7 and HCT-116 cancer cell lines. Compound 1d is highly cytotoxic against all tested cancer cell lines. Further investigation of compound 1d by Hoechst Staining and Fluorescence-Activated Cell Sorting Analysis (FACS) revealed that this compound causes apoptosis by cell cycle arrest at subG<inf>1</inf> phase. © 2014 Informa UK Ltd. All rights reserved.EnglishAnticancerbenzothiazolecytotoxicitypiperazinesulphorodamine Bantineoplastic agentbenzothiazole derivativefluorouraciln (6 ethoxybenzothiazol 2 yl) 2 [4 (o chlorophenyl)piperazinyl]acetamiden (6 ethoxybenzothiazol 2 yl) 2 [4 (o cyanophenyl)piperazinyl]acetamiden (6 ethoxybenzothiazol 2 yl) 2 [4 (p cyanophenyl)piperazinyl]acetamiden (6 ethoxybenzothiazol 2 yl) 2 [4 (p toluyl)piperazinyl]acetamiden (6 methylbenzothiazol 2 yl) 2 (4 cyclohexylpiperazinyl)acetamiden (6 methylbenzothiazol 2 yl) 2 [4 (2 methoxyethyl)piperazinyl]acetamiden (6 methylbenzothiazol 2 yl) 2 [4 (2 methoxyphenyl)piperazinyl]acetamiden (6 methylbenzothiazol 2 yl) 2 [4 (3,4 dichlorophenyl)piperazinyl]acetamiden (6 methylbenzothiazol 2 yl) 2 [4 (4 chlorobenzyl)piperazinyl]acetamiden (6 methylbenzothiazol 2 yl) 2 [4 (pyridin 4 yl)piperazinyl]acetamidepiperazine derivativesulforhodamine Bunclassified drugapoptosisArticlecancer cell linecell cycle arrestcell cycle G1 phasechemical structurecontrolled studydrug cytotoxicitydrug synthesisfluorescence activated cell sortinghumanhuman cellhuman cell culturein vitro studypriority journalproton nuclear magnetic resonanceArticle10.3109/14756366.2014.959513