Ahmadli, D.2023-02-162023-02-162022-05-190040-4039http://hdl.handle.net/11693/111427We report the first total synthesis of the biologically active fungal natural product daldiquinone (5), which was accomplished with a longest linear sequence of 8 steps in 41% overall yield. The construction of the unsymmetrical binaphthalene core was realized by a Suzuki-Miyaura cross-coupling in 88% yield on gram scale. Oxidation of naphthol 17 with IBX afforded the key naphthoquinone intermediate 18 in high yield (92%).EnglishDaldiquinoneNaphthoquinonesNatural productsSuzuki-Miyaura couplingTotal synthesisArticle10.1016/j.tetlet.2022.1538771873-3581