Korkmaz, Y.Çukur, TolgaPatel, V. M.2024-03-162024-03-1620230302-9743https://hdl.handle.net/11693/114823Conference Name: 26th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2023 Vancouver Date of Conference: 8 October 2023 - 12 October 2023Magnetic Resonance Imaging (MRI) produces excellent soft tissue contrast, albeit it is an inherently slow imaging modality. Promising deep learning methods have recently been proposed to reconstruct accelerated MRI scans. However, existing methods still suffer from various limitations regarding image fidelity, contextual sensitivity, and reliance on fully-sampled acquisitions for model training. To comprehensively address these limitations, we propose a novel self-supervised deep reconstruction model, named Self-Supervised Diffusion Reconstruction (SSDiffRecon). SSDiffRecon expresses a conditional diffusion process as an unrolled architecture that interleaves cross-attention transformers for reverse diffusion steps with data-consistency blocks for physics-driven processing. Unlike recent diffusion methods for MRI reconstruction, a self-supervision strategy is adopted to train SSDiffRecon using only undersampled k-space data. Comprehensive experiments on public brain MR datasets demonstrates the superiority of SSDiffRecon against state-of-the-art supervised, and self-supervised baselines in terms of reconstruction speed and quality. Implementation will be available at https://github.com/yilmazkorkmaz1/SSDiffRecon. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.en-USAccelerated MRICross-attentionMagnetic resonance imagingSelf-supervised learningTransformersConference Paper10.1007/978-3-031-43999-5_471611-3349