Kraitchman, D. L.Heldman, A. W.Atalar, ErginAmado, L. C.Martin, B. J.Pittenger, M. F.Hare, J. M.Bulte, J. W. M.2016-02-082016-02-0820030009-7322http://hdl.handle.net/11693/24482Background - We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results - Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16×107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion - MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.EnglishCellsContrast mediaMagnetic resonance imagingMyocardial infarctionAnimal cellAnimal experimentAnimal modelContrast enhancementDeviceFeasibility studyFluoroscopyHeart infarctionMesenchymeNonhumanNuclear magnetic resonance imagingPriority journalStem cellSwineTechniqueAnimalsInjectionsIronMyocardiumStem Cell TransplantationStem CellsSwineArticle10.1161/01.CIR.0000070931.62772.4E