Uz, E.Mustafa, C.Topaloglu, R.Bilginer, Y.Dursun, A.Kasapcopur, O.Ozen, S.Bakkaloglu, A.Ozcelik, T.2016-02-082016-02-0820092326-5205http://hdl.handle.net/11693/22574Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.EnglishAndrogen receptorDNAImmunosuppressive agentMethotrexateNonsteroid antiinflammatory agentArticleBlood samplingControlled studyDNA polymorphismFemaleGene frequencyHumanJuvenile rheumatoid arthritisMajor clinical studyPriority journalX chromosome inactivationAdolescentArthritis, Juvenile RheumatoidCase-Control StudiesChildChild, PreschoolChromosomes, Human, XFemaleGenetic Predisposition to DiseaseGenotypeHeterozygoteHumansMutationReceptors, AndrogenRisk FactorsX Chromosome InactivationArticle10.1002/art.24956