Chabchoub, G.Uz, E.Maalej, A.Mustafa, C. A.Rebai, A.Mnif, M.Bahloul, Z.Farid, N. R.Ozcelik, T.Ayadi, H.2016-02-082016-02-0820091478-6362http://hdl.handle.net/11693/22696Introduction The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases.EnglishAndrogen receptorCyclic citrullinated peptide antibodyHydroxychloroquineMethotrexatePenicillamineRheumatoid factorAutoantibodyAlleleAutoimmune thyroiditisChromosome analysisControlled studyFemaleGenetic associationGenetic predispositionHumanImmunosuppressive treatmentMajor clinical studyPhenotypePolymerase chain reactionX chromosome inactivationAutoimmune diseaseBloodEnzyme linked immunosorbent assayGeneticsMiddle agedRheumatoid arthritisThyroid diseaseX chromosomeAdultArthritis, RheumatoidAutoantibodiesAutoimmune DiseasesChromosomes, Human, XEnzyme-Linked Immunosorbent AssayFluorescent Antibody TechniqueGenetic Predisposition to DiseaseHumansPolymerase Chain ReactionThyroid DiseasesTunisiaArticle10.1186/ar2759