Türkşanlı Kaplan, Merve2016-01-082016-01-082011http://hdl.handle.net/11693/15111Ankara : The Graduate Program of Materials Science and Nanotechnology and the Institute of Engineering and Sciences of Bilkent University, 2011.Thesis (Master's) -- Bilkent University, 2011.Includes bibliographical references leaves 42-45.Photodynamic therapy (PDT) is a novel approach for the treatment of some cancers and other non-malignant diseases. PDT aims to kill cancer tissue by the generation of singlet oxygen as a result of excitation of the photosensitizer (PS) by illuminating with a light source at a certain wavelength. Mesoporous silica nanoparticles are promising in PDT issue due to their chemical inertness, biocompatibility, lowtoxicity, hydrophility and ease of surface modification. We have synthesized and characterized novel boradiazaindacene (BODIPY)-based PS that is covalently attached to the pore of mesoporous silica nanoparticles (MSNs). We have observed that near infrared absorbing photosensitizer attached MSNs successfully generate cytotoxic singlet oxygen.xii, 60 leaves, illustrationsEnglishinfo:eu-repo/semantics/openAccessBoradiazaindaceneDrug carrier systemMesoporous silica nanoparticlesPhotosensitizerPhotodynamic therapyTA418.9.P6 K37 2011Porous materials.Nanostructured materials.Photochemotherapy.Nanoparticles.ThesisB125581