Guran, Ş.Beyan, C.Nevruz, O.Yakıcıer, C.Tunca, Y.2016-02-082016-02-0820050141-9854http://hdl.handle.net/11693/24082Li-Fraumeni syndrome is a familial cancer syndrome characterized by different tumors and hereditary p53 mutations. Here, a chronic myeloid leukemia-like syndrome case in a Li-Fraumeni syndrome family with del (12) (p12) cytogenetic abnormality was presented. A hereditary p53 mutation (pro309ser) supported the Li-Fraumeni syndrome diagnosis in this family. This syndrome was characterized by the clonal myeloproliferative accumulation in bone marrow and peripheral blood with negative bcr/abl gene rearrangement finding. The etiology of this rare syndrome is still unclear. This is the only chronic myeloid leukemia-like syndrome case reported in a Li-Fraumeni syndrome family. Del (12) (p12) was observed in leukemias except chronic myeloid leukemia-like syndrome. The deletion in chromosome 12pl2 with hereditary p53 mutation should have a critical role in chronic myeloid leukemia-like syndrome etiology in our case. © 2005 Blackwell Publishing Ltd.Englishbcr/abl translocationChronic myeloidLeukemia-like syndromeLi-Fraumeni syndromep53Philadelphia chromosomeDNAProtein p53RNAArticle10.1111/j.1365-2257.2005.00679.x