Aytac Z.Dogan, S.Y.Tekinay, T.Uyar, Tamer2016-02-082016-02-0820140927-7765http://hdl.handle.net/11693/25569Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. © 2014 Elsevier B.V.EnglishAllyl isothiocyanateAntibacterial activityElectrospinningNanofibersReleaseβ-CyclodextrinBacteriaCyclodextrinsElectrospinningEscherichia coliAllyl isothiocyanateAnti-bacterial activityCyclodextrin complexesElectrospinning processElectrospun nanofibersInclusion complexationPoly (vinyl alcohol) (PVA)ReleaseNanofibersallyl isothiocyanatebeta cyclodextrinnanofiberpolyvinyl alcoholallyl isothiocyanateantiinfective agentbeta cyclodextrinbeta cyclodextrin derivativeisothiocyanic acid derivativenanofibersolution and solubilityarticlebactericidal activitybacterium colonycomplex formationconcentration (parameters)controlled studycrystal structureelectrospinningEscherichia colievaporationmass fragmentographynanoencapsulationnonhumanpriority journalproton nuclear magnetic resonancescanning electron microscopyStaphylococcus aureustensile strengthbacterial countchemistrydrug effectsdrug releasegrowth, development and agingmicrobial sensitivity testnanotechnologyproceduressolution and solubilityultrastructureX ray diffractionAnti-Bacterial Agentsbeta-CyclodextrinsColony Count, MicrobialDrug LiberationEscherichia coliIsothiocyanatesMicrobial Sensitivity TestsNanofibersNanotechnologyProton Magnetic Resonance SpectroscopySolutionsStaphylococcus aureusX-Ray DiffractionArticle10.1016/j.colsurfb.2014.04.006