Arkin, L. M.Moon, J. J.Tran, J. M.Asgari, S.O'Farrelly, C.Casanova, J. -L.Cowen, E. W.Mays, J. W.Singh, A. M.Drolet, B. A.Aiuti, A.Belot, A.Bolze, A.Bondarenko, A.Sediva, A.Shcherbina, A.Planas, A. M.Condino-Neto, A.Pujol, A.Catherine, B.Flores, C.Rodríguez-Gallego, C.Prando, C.Dalgard, C. L.Roger, C.Mansouri, D.van, de Beek, D.Vinh, D. C.Hsieh, E.Andreakos, E.Haerynck, F.Uddin, F.Casari, G.Novelli, G.Pesole, G.Meyts, I.Tancevski, I.Fellay, J.Tur, J.Kisand, K.Okamoto, K.Mironska, K.Abel, L.Renia, L.Ng, L. F. P.Shahrooei, M.Soler-Palacín, P.Brodin, P.Pan-Hammarström, Q.Halwani, R.Perez, de Diego, R.Al-Muhsen, S.Espinosa-Padilla, S.Okada, S.Özçelik, TayfunTayoun, A. A.Karamitros, T.Mogensen, T. H.Lau, Y. L.2022-04-272022-04-2720210022-202Xhttp://hdl.handle.net/11693/78166Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.EnglishArticle10.1016/j.jid.2021.05.0241523-1747