Gao J.Aksoy, B. A.Dogrusoz, U.Dresdner, G.Gross, B.Sumer, S. O.Sun, Y.Jacobsen, A.Sinha, R.Larsson, E.Cerami, E.Sander, C.Schultz, N.2016-02-082016-02-0820131945-0877http://hdl.handle.net/11693/21019The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics. © 2013 American Association for the Advancement of Science.EnglishBRCA1 proteinBRCA2 proteinCetuximabEpidermal growth factor receptor 2ErlotinibGefitinibMicroRNATrastuzumabBioinformaticsCancer geneticsCancer survivalColorectal cancerCopy number variationDisease free survivalDNA methylationGene expressionInformation processingInternetMedical information systemMutationOverall survivalPriority journalProteomicsRectum carcinomaComputer programGenetic predispositionGeneticsHumanInformation retrievalMethodologyNeoplasmPathologyReproducibilityGene expression profilingGene regulatory networksGenetic predisposition to diseaseGenomicsInformation storage and retrievalReproducibility of resultsSoftwareArticle10.1126/scisignal.20040881937-9145